ECE2022 Eposter Presentations Pituitary and Neuroendocrinology (211 abstracts)
Demonstration of the effects of asprosin on the sense of smell in female rats with hidden cookie test
Zeynep Dila Öz 1 , Gö khan Zorlu 2 , Fatih Tan 1 , Gaye Gö ksu Avcu 1 , Emine Kacar 1 , Abdullah Yasar 3 , Ihsan Serhatlioglu 2 , Haluk Kelestimur 1 & Bayram Yilmaz 4
1Firat University Faculty of Medicine, Physiology, Elazig, Turkey; 2Firat University Faculty of Medicine, Biophysics, Turkey; 3Fırat University, Vocational School of Health Services, Turkey; 4Yeditepe university, School of Medicine, Turkey
Purpose: Asprosin is a novel glucogenic adipokine produced by the fibrillin 1 (FBN1) gene that is generated and released by white adipose tissue during fasting. Asprosin hormone has been shown to improve the sense of smell in wild-type mice by activating the OLFR734 receptor and decreasing the time it takes for them to discover hidden food. The purpose of this study was to determine the effects of asprosin on the sense of smell in female rats through the use of a hidden cookie test.
Materials and methods: Twenty-four female Sprague-Dawley rats were randomly divided into 2 groups (n=12) as control and asprosin. Asprosin and saline were intraperitoneally given at a dose of 500 ng/kg and 1 ml/kg to asprosin and control groups, respectively at 14.00 every day for eight weeks. The hidden cookie test was performed four times a day during ad libitum feeding, and the final experiment was repeated 24 h after fasting when all animals were in the estrous phase. Cookies (Chocapic, Nestle) were buried at a depth of 3 cm. They were recorded from 4 angles for 10 minutes. The finding time of the cookie was scored in seconds. T-test was used for the evaluation of the data. In all analyses, P<0.05 was considered statistically significant.
Results: In the hidden cookie test, the meantime of the control group was 445.29±64.58 seconds while it was 450.45±63.46 seconds in the asprosin group (P>0.05). Twenty-four hours after fasting, the average time in the asprosin group was 379.58±55.04 while it was 208.83±58.28 seconds in the control group (P<0.05).
Conclusion: It was found that there was no significant difference in the hidden cookie test performed when female rats were fed. However, asprosin hormone significantly increased the sense of smell due to the test performed after 24 h after fasting. Key words: Asprosin, adipokine, smell, hidden cookie test
Acknowledgment: This study was supported by TUBITAK (Project:220S744).
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