Endocrine Abstracts

Introduction: Pituitary adenomas represent about 10 to 20% of all intracranial tumors. They are usually classified according to their size into pico-adenomas, micro-adenomas and macro-adenomas, but can also be classified according to their secretory properties into secreting or nonfunctional adenomas. In this study, we describe the clinica, paraclinica, therapeutic and evolution features of pituitary adenomas in our center.

Material and methods: A retrospective and descriptive study, over a period of 6 years, including 92 patients with pituitary adenoma, followed-up in the Endocrinology-Diabetology and Nutrition department of Mohammed VI University Hospital Center of Oujda, Morocco.

Results: The mean age of the patients was 44 years with a sex ratio (F/M) of 1.6. The clinical features were dominated by headaches and/or visual changes and were reported in 59.8% of patients. Radiologically, macroadenomas were by far the most frequent (70.7%). Hypopituitarism was found in 28.3% of cases. In our study, non-functional adenomas were the most frequent etiology (26.1%), followed by Cushing’s disease (22.8%) and prolactinomas (20.6%). Somatotropic adenomas were found in 17.4% of cases. Fifty-eight percent of the patients underwent transphenoïdal surgery, of which 9.8% received radiotherapy. Medical treatment was considered in 63% of patients.

Conclusion: The management of pituitary adenomas must be multidisciplinary engaging neurosurgeons, endocrinologists, radiologists and ophthalmologists. The decision of the therapeutic choice is taken according to several criteria including: size, secreting or functional character, invasive character and response to medical treatment\.. [1]. All the files of our patients were discussed in a multidisciplinary meeting entitled ‘Staff of the pituitary gland’.

Bibliography: [1] Molitch ME. Diagnosis and Treatment of Pituitary Adenomas: A Review. JAMA. 2017 Feb7;317(5):516-524