ECE2022 Eposter Presentations Pituitary and Neuroendocrinology (211 abstracts)
Clinical, paraclinical and genetic features of diabetes insipidus
Fatma Mnif 1 , Hana Charfi 1 , Fatma Abdelhédi 2 , Malek Bouassida 2 , Mouna Elleuch 1 , Dhoha Ben Salah 1 , Mouna Mnif 1 , Nabila Rekik Majdoub 1 , Nadia Charfi 1 , Faten Haj Kacem Akid 1 , Hassen Kammoun 2 & Mohamed Abid 1
1Hedi Cheker University Hospital, Endocrinology, Tunisia; 2Hedi Cheker University Hospital, Genetics, Tunisia
Introduction: Diabetes insipidus (DI) is a rare pathology. The advent of hypothalamic-pituitary MRI has made it possible to make a positive diagnosis by avoiding the water restriction test (WRT). The etiological diagnosis is still a challenge in view of the diversity of diseases involved, which influences the therapeutic management and prognosis.
Work Objectives: The objectives of our work were to describe the clinical, paraclinical and genetic features of DI.
Patients and Methods: We conducted a retrospective and descriptive study of all cases of DI collected in the endocrinology department of Hèdi Chaker University Hospital, Sfax Tunisia during a 21-year period (2000-2021).
Results: We collected 44 patients, with a mean age of 53.2±16.05 years and a sex ratio M/F of 0.7. The most frequent reason for consultation was SPUPD in 70.5% of cases. The severity of SPUPD was variable: polyuria > 5l/24 h in 75% and polydipsia > 10l/24 h in 38%. There were no adverse effects of SPUPD described in our study. The positive diagnosis was made by WRT in 13 patients, and bases on hypothalamic-pituitary MRI in the other cases: an abnormal spontaneous T1 hyper signal was present in 70.4% of patients. Three patients had a nephrogenic DI, one of which was drug-induced (lithium intoxication) and the other two of genetic origin (AQP2 mutations). CDI was identified in 41 patients, 2 of whom had partial diabetes and 5 had transient diabetes. The most frequent etiologies were: post neurosurgical interventions (24.4%), pituitary tumors (17%) and lymphocytic hypophysitis (14.6%). An idiopathic origin was present in 12.2% of cases. Minirin treatment was initiated in all patients suffering from CDI with a clear clinical improvement. For NDI, an association with indomethacin or thiazide diuretic was necessary.
Conclusions: At the end of this work, we insist on the necessity of a better knowledge of this pathology, allowing an early diagnosis and a management, only guaranteeing a better prognosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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