Endocrine Abstracts

Hyperthyroidism is a clinical situation characterized by an excess of thyroid hormones in the circulation, the most common etiology of which is Graves’ disease. Its treatment is based on ATS, iodine 131 and surgery. The iratherapy, object of our study, is a treatment of current practice. It is a simple and radical treatment whose goal is to switch to euthyroidism or hypothyroidism. In case of failure or recurrence, a 2nd or even a 3rd cure is prescribed. We conducted a retrospective, descriptive study with the aim of clarifying the future of patients followed in the nuclear medicine department of the CHU Tlemcen after metabolic radiotherapy with iodine 131 for Graves’ disease. Out of 101 patients, 3 groups were identified: the first with 87 patients having received a single course of iodine 131, the average activity administered is 9.89 mCi, the success rate at 18 months is 75%. The second group with 13 patients who received 2 courses of iodine 131 whose mean activity administered in the first course was 10.01 mCi, after failure and persistence of hyperthyroidism they received a second course whose mean activity administered is of 10.11 mCi, the success rate at 18 months this time is 77.7%. Finally, a third group consists of a single patient who received 3 courses of iodine 131 with a cumulative activity of 35.08 mCi. The latter found himself in hypothyroidism after the 3rd treatment. Radiation therapy has its place as a therapeutic alternative for Graves’ disease after failure or intolerance to medical treatment