ECE2022 Eposter Presentations Late Breaking (59 abstracts)
Spectrum of radiological abnormalities of children with growth hormone deficiency at the endocrinology-diabetology-nutrition department of oujda’s university hospital
Wahiba Abdellaoui 1 , Nada El Yamani 1 , Tahri Abir 1 , Siham Rouf 1 , 2 & Hanane Latrech 1
1Mohammed VI University Hospital, Medical School, Mohammed the First University, Department of Endocrinology-Diabetology-Nutrition, Morocco; 2Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, Mohammed the First University, Morocco
Introduction: Growth hormone deficiency (GHD) is a non-exceptional cause of short stature. Hormonal evaluation and hypothalamic-pituitary MRI are essential to establish the etiological diagnostic. The objective of our study is to assess the different pituitary lesions found in a group of children with GHD.
Patients and methods: This is a retrospective longitudinal study of 36 cases of GHD who underwent pituitary MRI examination collected in the Endocrinology-Diabetology Department of Mohammed VI University Hospital.
Results: The mean age at diagnosis was 11.6 years with a sex ratio (M/F) of 1.57. Mean height Z-score at time of diagnosis was −4.3 SD. The mean bone age (BA) at the time of diagnosis was 7.6 years. The delay of BA over the chronological age was of 4.2 years on average. The diagnosis of total GHD was found in 66.7% of patients and partial GHD in 33.3% of patients. The isolated deficiency was noted in 52.8 % of cases and multiple deficiencies in 47.7% of cases. Magnetic resonance imaging of the hypothalamic-pituitary region was normal in 33.3% of cases. Pituitary stalk interruption was observed in 41.7% of patients, pituitary hypoplasia was observed in 11.1% of patients, an empty sella was observed in 8.3% of patients, and agenesis of anterior pituitary in 5.6% of patients.
Conclusion: The multiplanar capability of MR imaging plays an important role in the assessment of the hypothalamic-pituitary area and in determining the underlying cause of various pituitary diseases in GHD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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