Endocrine Abstracts

Objective: Rosacea is an inflammatory dermatosis. Telangiectasias, edema, erythema, and acneiform eruptions are the main symptoms. Several genetic and environmental factors have been linked to rosacea; however, the etiology of the disease is still not known. It is considered a systemic disease rather than a skin disorder. Endocrine-disrupting chemicals are substances people are exposed to through water, food, self-care products, and the environment. They interfere with normal hormonal functions and can also enter the body through the skin. Bisphenol A (BPA) and pentachlorophenol sodium (PCS) are two substances associated with different diseases. The possible association of these substances with rosacea is not known. We aimed to determine BPA and PCS levels in patients with rosacea.

Methods: We conducted a prospective study in a training hospital. Thirty-four patients with Rosacea (18F/16M; mean age 48.5±11) and 34 age and sex-matched healthy controls (20 F/14 M; mean age 48.2±10.2) were included. Main anthropometric measures, plasma glucose (FPG), insulin, lipids, TSH, BPA, and PCS levels were measured.

Results: Age, weight, BMI, FPG, and TSH were similar between the two groups. CRP levels were higher in patients with rosacea (9.6±3.4 and 3.7±1.6 for patients and healthy controls, respectively, P<0.001). Serum BPA levels were 55.8±14.4 and 51.9±19.2, and PCS levels 63.3±45.9 and 68.6±40.8 for patients and healthy controls, respectively. There was no significant difference between BPA and PCS levels (P>0.05).

Conclusions: CRP levels were higher with patients with rosacea compared to healthy controls; however, BPA and PCS levels were not different from healthy controls.