Endocrine Abstracts

Adrenocortical tumor is a rare malignant tumor of adrenal location. With a poor prognosis that can be improved by rapid diagnosis and adequate early management, hence the importance to evoke this etiology in front of any atypical adrenal mass or any suggestive clinical or biological context. The objective of our modest work is to report through a retrospective study the profile of adrenocortical tumors treated in our service over a period of 13 years from 2007 to 2020. Thirty (30) patients were collected with a middle age of 45 years (27 to 74 years) with a slight female predominance of 60%. A family history of neoplasia was noted in 5 patients (16.66%) and breast neoplasia in a single patient. The most frequent mode of revelation is represented by abdominal pain observed in 56.66% of cases. Hypercortisolemia is found in 40% of cases. Morphologically, the size of the tumor varies from 66 to 180 cm with an average of 110 cm. At least one metastasis was found in 10 patients (33.33%), dominated by hepatic location. 50% of our patients benefited from surgical excision of the tumor and 6.66% underwent a biopsy only. 77% of our patients received adjuvant treatment with mitotane supplemented by chemotherapy in 30% of cases. Only two patients received adjuvant radiotherapy (6.66%). The evolution was marked by remission in 33.33% of cases with an average survival of 5 years and death noted in 50% of patients. In conclusion : Adrenal carcinoma can be seen at any age with a peak frequency in the fifties, affects both men and women with a slight female predominance. Large tumors whose treatment is surgical associated with neoadjuvant treatment in the majority of cases. Unfavorable prognosis, but optimized management can improve survival.