Endocrine Abstracts

Introduction: We explored utility of ankle-brachial index (ABI), toe brachial index (TBI), Albumin Creatinine Ratio (ACR), Low Density Lipoprotein Cholesterol (LDL-C) in context with change in HbA1c

Methods: We conducted an observational study in 25 T2DM on standard care in real world setting

Results: The mean follow up (months) was 19.2 (±6, range 12). The mean age (years) was 57 (±12, 95% CI 52 to 63). Initially 36% (9/25) had HbA1c < 7% which increased by 16% with an addition of four patients with HbA1c < 7%, 52% (13/25). Additional four patients achieved LDL-C < 100 mg/dl, 72% (18/25) increase to 88% (22/25). Initially, TBI Left was within range (0.5-0.75) in 8% patients (2/25) which increased to 16% (4/25). ACR was unchanged with < 30 in 80% of patients (20/25). There was a decrease in the number of patients with target range of ABI- right and left from 80% (20/25) to 68% (17/25) and 72% (18/25) to 68% (17/25) patients, respectively. There was no significant corelation between the change in HbA1c and change in LDL (r -0.14, 95% CI -0.51 to 0.26, P=0.47 ns), ABI- right (r -0.18, 95% CI -0.54 to 0.22, P=0.36 ns), ABI- left (r 0.25, 95% CI -0.15 to 0.59, P=0.21 ns), TBI- right (r -0.14, 95% CI -0.15 to 0.26, P=0.48 ns), TBI- left (r -0.32, 95% CI -0.63 to 0.08, P=0.11 ns), ACR (r 0.06, 95% CI -0.34 to 0.44, P=0.77 ns). Table: Change in markers

Conclusion: The change in HbA1c was independent of the change in the markers of peripheral arterial disease and nephropathy. The results need corroboration with larger studies.