Endocrine Abstracts

Obesity is considered a chronic metabolic disease that occurs at any age. Regulation of body weight in the body is carried out through complex interaction of a complex of interrelated systems that control the body’s energy system. Energy imbalance is the cause of obesity and overweight, in which the supply of energy from food exceeds the energy needs of the body. Obesity is closely related to impaired appetite regulation, and hypothalamus is a key place of neural regulation of food consumption. The nucleus of the hypothalamus is connected and interdependent on receiving, integrating and sending hunger signals to regulate appetite.

Purpose of The Study: To identify markers of food behaviour.

Materials and Methods: The screening was carried out to identify eating disorders in 200 men and women aged 18 to 35 years with overweight and obesity and to check the effects of Orexin A and Neuropeptide Y markers. A questionnaire and questionnaires were conducted with over 200 people aged 18 to 35 years. Questionnaires were for abnormal eating habits and hidden depression (Zung Anxiety Rating Scale- ZARS). Anthropometry is measured by waist circumference, hip circumference, body mass index, weight, height. Based on the results of the collected data, were divided three groups: People with obesity; People with overweight; Control group of healthy people.

Results: Of the 200 analysed persons, 86% had eating disorders. Of these, 60% of eating disorders were associated with childhood. According to the result ZARS: Normal condition was about 37%, mild depressive disorder 20%, moderate depressive disorder 25% and 18% of people suffered from severe depressive disorder without knowing it. First group of people with obesity had eating disorders, moderate and severe depressive disorder, second group was overweight with mild depressive disorder. According to laboratory data, the first group had the lowest concentration of Orexin A and Neuropeptide Y in blood serum.

Conclusion: Overweight and obesity are the first signal of many diseases. Prevention and detection of these problems will avert various illness, including type 2 diabetes. Obesity aetiology is associated with eating disorders wich leads to anxiety conditions and signal transmission of the orexinorghetic system of the hypothalamus.

Keywords: obesity, energy imbalance, hypothalamus, orexin A, neuropeptide Y.