Endocrine Abstracts

Introduction: Non-alcoholic fatty liver disease (NAFLD), is a frequent cause of chronic liver disease and is widely associated with metabolic syndrome. When associated with diabetes, it can increase the risk of cardiovascular events. The aim of this study is to evaluate the relationship between hepatic steatosis and the occurrence of cardiovascular events in patients with type 2 diabetes.

Method: It is a retrospective study, including 184 type 2 diabetic patients, conducted in the department C of the National Institute of Nutrition of Tunis during the year 2021.

The diagnosis of hepatic steatosis was retained by an abdominal ultrasound.

Results: Our population was composed of 66 men and 118 women. The mean age of the patients was 61 +/- 10 years, and the average duration of diabetes was 13 +/- 8 years. The prevalence of NAFLD was 29.3%. A clear female predominance was noted in patients with NAFLD(77.8%). Diabetic patients with NAFLD had dyslipidemia in 88.9%. The majority of patients had poorly controlled diabetes with a mean HB1AC of 10.4 +/- 2%. The average body mass index of these patients was 35+/- 5 kg/m². Hepatic steatosis is positively correlated with coronary artery disease (P=0.016) and high blood pressure (P=0.000). Morever a significant association was noted with hyper uricemia (P=0.021) and obesity (P=0.000).

Conclusion: The coexistence of type 2 diabetes and NAFLD increases the occurrence of cardiovascular events and disturbs the glycemic balance of diabetic patients, which underlines the importance of screening for this hepathopathy.