Endocrine Abstracts

Introduction: The prevalence of obesity is increasing in the world. It constitutes a major risk factor associated with diabetes, hypertension, dyslipidemia and cardiovascular diseases. The aim of our work is to compare the metabolic profile of morbid obesity with that of moderate to severe obesity.Patients and methodsIt is a Retrospective, descriptive and analytical study, including 63 obese patients, followed at the endocrinology, diabetology and nutrition department of the CHU Mohamed VI Oujda. The patients were divided into two groups: Group 1 (G1: moderate to severe obesity): 37cases (BMI:30 to 40 kg/m²), Group 2 (G2: morbid obesity): 26 cases (BMI≥40 kg/m²). Collected data were analysed using SPSS V24 software.

Results: The mean age of the patients was 30.5±16.9 years in G1 and 39.8±12.5 years in G2. A female predominance was noted in the 2 groups with a Sex-ratio F/M (G1):2.7 and (G2):7.6. The mean BMI in G1 was 35±2.9 kg/m^² and 47.8±5.9 kg/m^² in G2. The mean waist circumference was higher in G2 (165.6 cm vs 111.2 cm). The prevalence of diabetes and pre-diabetes was 35.2% and 43.3% (G1) vs 30.7% and 38.5% (G2) respectively (P =0.05). The prevalence of hepatic steatosis was higher in G2 compared to G1 (69.2% vs 48.6%) but without significant difference (P = 0.5).The mean uricemia was 54±14.5 mg/l (G1) and 65.3±12 5 mg/l (G2). In contrast, the prevalence of dyslipidemia was higher in G1 (32.4%) compared to the group having morbid obesity (26.9%) with a highly significant difference (P = 0.008).Discussion/ConclusionObesity is an excess of body fat with harmful consequences for health. It has been defined as a disease by the World Health Organization since 1997 in view of its epidemic dimension and its somatic, psychological and socio-economic repercussions. The main metabolic complications of obesity are associated with the phenomenon of insulin resistance and are included in the metabolic syndrome. Several studies suggest that despite a greater accumulation of fat, morbid obesity is not characterized by a more deleterious metabolic profile than moderate and severe obesity. The results of our study are also in line with those of the literature, which show that the severity of obesity is not significantly correlated with metabolic risk.

Keywords: Morbid obesity, moderate and severe obesity, metabolic profile