Endocrine Abstracts

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of obese patients admitted to the Endocrinology Research Center between February 2019 and December 2020. We included 45 adults (41 women and 4 men, median age 57.5 years) with diabetes mellitus type 2 (median duration of disease 8 years, 5 newly diagnosed) and morbid obesity (BMI>40 kg/m²). Anthropometric (BMI) and metabolic (fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), C-peptide) parameters were determined before surgery and at 6, 12 months after. Statistical analysis was performed with the use of Statistica v. 13.3 (TIBCO Software Inc., Palo Alto, CA, USA). Data is presented by medians and interquartile ranges (Median, (25;75)). There were carried out a comparative analysis of three dependent groups for quantitative data using the Friedman criterion, pairwise comparison of groups for quantitative data using the Wilcoxon criterion. The initial critical level of significance in testing statistical hypotheses was assumed to be 0.05. Results In the studied group the baseline median BMI was 51 kg/m² (44.3; 55.6), FPG 7.4 mmol/l (6.6; 9.0), HbA1c 7.2% (6.5; 8.5), С-peptide 4.5 ng/ml (4.3; 5.1). 6 months after LMGB the median BMI was 38.6 kg/m² (35.5; 42.1), FPG 5.3 mmol/l (4.9; 6.2), HbA1c 5.5% (5.3; 6.2), С-peptide 2.5 ng/ml (2.3; 3.9); 1 year after - BMI 31.6 kg/m² (28.65; 34.2), FPG 4.9 mmol/l (4.4; 5.3), HbA1c 5.7% (5.1; 5.9), С-peptide 2.2 ng/ml (1.9; 3.2). Comparing three groups differences in HbA1c levels were revealed (n = 11, P < 0.001). Difference between groups of 6 and 12 months after LMGB (n = 10, P > 0.05) was significantly less than before LMGB and 6 months after (n = 23, P < 0.001), before and 12 month after LMGB (n = 18, P < 0.001) in further pairwise comparison. Conclusion Weight loss was accompanied by a significant improvement of carbohydrate metabolism. A more pronounced decrease in body weight and improvement of metabolic parameters were observed in the first 6 months after surgery.