Endocrine Abstracts

Introduction: Parkinson’s disease is considered the most common chronic neurodegenerative disease that often affects the elderly, rarely the young. Meanwhile, Diabetes mellitus is the most common chronic metabolic disease. Because of the increase in the prevalence of diabetes and neuro-vegetative diseases, we can wonder about the relationship between the two diseases. We report the case of a patient with type 2 diabetes mellitus associated with young onset Parkinson’s disease

Case: A 44-year-old female patient, has been followed for type 2 diabetes mellitus for 5 years under Metformin and insulin with a history of Parkinson disease diagnosed 2 years ago in front of resting tremor, slowness of movements and muscular rigidity. She was put on L-Dopa with favorable clinical evolution.Discussion & conclusionThe possibility of a relationship between Parkinson’s disease and T2DM has been well studied. A few epidemiological studies have shown that diabetes is a major risk factor that accelerates the deterioration of motor function or cognitive status. T2DM shares some common pathogenic traits with PD. For example, high levels of immune cells, cytokines and chemokines have been described in pancreatic islets of patients with T2DM, while microglia activation seems to play a central role in PD progression. Similarly, the role of mitochondrial dysfunctions and oxidative stress in both T2DM and PD is now well established.