ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Plasmalogen levels are associated with the severity of diabetic neuropathy
Nilufar Akhrarova 1 , Talat Saatov 2 , Munojat Salimova 3 , Mehriniso Khamraeva 4 , Bakhodir Zaynutdinov 2 & Zulaykho Shamansurova 2,5
1City Specialised Outpatients Clinic, Endocrinology, Tashkent, Uzbekistan; 2Institute of Biophisics and Biochemistry at the NUUz, Metabolomics, Tashkent, Uzbekistan; 3City Specialised outpatients Clinic, Physiotherapy, Tashkent, Uzbekistan; 4City Specialised Outpatients Clinic, Cardiology, Tashkent, Uzbekistan; 5Tashkent Pediatric Medical Institute, Endocrinology, Tashkent, Uzbekistan
Backgrounds: Diabetes mellitus is a complex disease accompanied by the development of complications. In addition to the classic hyperglycemia and dyslipidemia, a number of other factors are involved in the pathogenesis of complications. Plasmalogens disturbances participates in nerve tissue degeneration.
Materials and methods: In 76 people with DM2 plasma and erythrocytes membranes plasmalogenes measured and compared according to diabetic neuropathy.
Results: Blood plasma plasmalogenes and erythrocytes membranes plasmalogens level shown decreased in patients with DM2 in compare with people without diabetes. When results analysed according to severity of diabetic nephropathy Blood plasma and erythrocytes membranes plasmalogens levels showed linkage. Blood plasma plasmalogens level were significantly differs between the groups and shown in 2.4 and 3.1 times lower in DN1 and DN2 groups. Whereas erythrocytes membranes plasmalogenes were more lower and showed lowering in DN1 groups in 3.6 times and DN2 groups in 4.2 times.
Conclusion: Blood plasma and erythrocytes membranes plasmalogens have linkage with severity of DN and involved into pathogenesis of neuropathy by neurodegeneration.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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