Endocrine Abstracts

The purpose of the study is to study the clinical and hormonal features of diabetes mellitus 2 (DM) associated chronic heart failure (CHF).

Material and research methods: For the period 2015-2021, 185 patients were identified as an object of study, and 185 patients based on the materials of their preparations into therapeutic and prophylactic institutions of Andijan from 30 years and older. Patients were distributed to 3 groups: 1 gr. are patients with DM 2 type + CHF - 65 patients,2 gr. are patients withDM 2 type without CHF - 60 patients, 3gr - these are patients with CHF without DM 2 type - 60 patients. Patients were fulfilled with general, biochemical, hormonal, genetic blood tests, as well as ECG, ECHC and other instrumental research.

Results: The average values of the N-terminal fragment of the Brain natriuretic peptide (NT-proBNP) were reliably different in all groups, and at the same time they were significantly higher in the group of patients with DM 2 + CHF compared with the parameters of patients with insulated CXN. In the study of the aldosterone, elevated average values were found in all groups, in patients with CHF, the indicators are reliable higher than in the group of patients with DM 2 type, in the group of patients with DM 2, in combination with CHF, the indicators were the highest, reliably distinguish from indicators of patients with DM 2 type and unreliable in comparison with the CHF Group. Renin levels in groups were significantly higher than the upper limit of the norm lying. However, it should be noted that in the DM 2 + CHF group, the indicators statistically significantly exceeded the indicators in the first two groups.

Conclusions: 1) Chronic hyperglycemia and activation of RAAS are pathogenetic factors that are aggravated by chronic heart failure in patients with 2-type diabetes. 2) Increasing the concentration of NTproBNP in all patients of the 2-type diabetes with concomitant CHF, as well as high sensitivity and specificity of the test proves the value of this marker for the diagnosis of CHF.