Endocrine Abstracts

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.

Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-sectional study in patients with DM1 followed up in the Diabetes Clinic of the Hospital Universitario San Cecilio, Granada. Weight (kg) and height (m) were determined and BMI (kg/m^²) was calculated. The recruited individuals were classified according to BMI > or < 25. Demographic variables (age in years), metabolic variables (years of disease, insulin sensitivity factor -FSI- and glycosylated hemoglobin determined by analysis (HbA1c)) and body composition (measurement with AKERN^® bioimpendanciometry of fat-free mass (FFM) in%, skeletal muscle mass (SMM) in kg. Calculation of skeletal muscle mass index (SMMI) in kg/m²).

Results: Forty persons with DM1 were included. 48% had BMI > 25, mean age 43±15 years and suboptimal glycemic control in both groups (BMI<25: 7.3±1.2 vs BMI > 25: 7.8±1.1, P = 0.21).

Conclusions: In persons with DM 1 and overweight or obesity, parameters related to less muscle mass and higher insulin requirements are detected, a context associated with insulin resistance. It could be important to establish strategies aimed at maintaining a healthy weight (muscular strength and resistance exercise tables together with a Mediterranean pattern diet avoiding excess calories and optimizing the insulin therapy dose) to reinforce muscular behavior and increase insulin sensitivity, especially in diabetics with more years of evolution with the aim of avoiding metabolic deterioration.