ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Assessment of hypoglycemic properties of extracts from some medicinal plants in the experimental diabetes model
Talat Saatov 1 , Elvira Ibragimova 1 , Sanobar Irgasheva 1 , Mokhammad Mustafakulov 1 , Malika Salakhutdinova 2 , Tokhir Ishankhodjaev 1 , Nigora Samarkhodjaeva 1 & Bakhodyr Zainutdinov 1
1Institute of Biophysics and Biochemistry under Mirzo Ulugbek National University of Uzbekistan, Metabolomics, Tashkent, Uzbekistan; 2A.S. Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan
Phytotherapy is the integral part of the combined treatment for diabetes mellitus. A large number of plants possessing hypoglycemic activity are described in the literature, but only small part of them is in use. Hypoglycemic effect of medicinal plants is preconditioned by the wide spectrum of compounds with biological activity in their composition. Flowers of carthamus (Carthamus tinctorius) and leaves of celery (Apium graveolens) are known to possess a number of therapeutic effects. In combination, bioactive compounds are known to amplify each other’s effects. In this connection, we have studied hypoglycemic activity of aqueous extracts of carthamus flowers and celery leaves, as well as the mixture of their extracts in rats with alloxan diabetes. The extracts were administered intragastrically for 2 weeks. The experimental animals were divided into 5 groups. Intact animals were included into the 1st group, the 2nd groups consisted of animals with alloxan diabetes (alloxan controls), the 3rd one included those administered with carthamus flowers, the 4th group consisted of those administered with celery leaves; animals with alloxan diabetes administered with the mixture of carthamus flowers and celery leaves (1:1) were included into the 5th one. Our findings demonstrated the reduction in the blood glucose of all animals with experimental diabetes after a course administration of the extracts, as compared to the alloxan controls. Thus, blood glucose in rats with alloxan diabetes for 2 weeks administered with the mixture of carthamus flowers and celery leaves was found to reduce from 18.4 mmol/l to 5.7 mmol/l and 8.5 mmol/l. respectively, while in rats with alloxan diabetes it declined due to regeneration of β-cells to 13.5 mmol/l. Following the course administration of the extracts, the blood glucose in animals similarly reduced reaching the normal parameters. Hypoglycemic effect of the extracts under study increased in this order: celery extract, carthamus-celery mixture and carthamus extract.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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