ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Impact of bariatric surgery on body composition and cognition: a pilot study
Andreu Simó-Servat 1,2 , Montserrat Ibarra 1 , Mireia Libran 1 , Nuria Alonso 1 , Silvia Rodriguez 1 , Montse Ramos 1 , Veronica Perea 1 , Luis García-Pascual 1 , Aida Orois 1 , Carmen Quirós 1 & Maria Jose Barahona Constanzo 1
1Hospital Universitari Mutua de Terrassa, Endocrinology, Terrassa, Spain; 2Terrassa, Endocrinology, Terrassa, Spain
Aim: Bariatric surgery (BS) modifies body composition. The aim of the study was to establish the first step toward the introduction of the ultrasound (US) and bioelectrical impedance analysis (BIA) in the evaluation of body composition before and after BS. In addition, as obesity was shown to be related to global cognitive decline, we aim to determine possible changes in cognitive test before and after BS.
Material and Methods: a prospective pilot study of patients with obesity who underwent BS in our hospital. Fat mass (FM) and lean mass (LM) were calculated by BIA, and skeletal muscle index (SMI) was used for estimating muscle mass. We measured thigh muscle thickness (TMT) and subcutaneous fat (SF) of quadriceps by US. In the same visit, Montreal Cognitive Assessment (MOCA) test was done. All subjects were assessed 1 month before surgery and 12 months after it.
Results: 32 patients were included (75% female, mean age: 40.15 years, mean BMI: 43.79 kg/m2). BS reduced BMI 6,63 ± 1,25 kg/m2 on average (P = 0.001). About body composition, significant reductions in FM (7.26 ± 0.99 kg, CI 95% 5.23 to 9.29, P = 0.001) and SF (0.24 ± 0.08 cm, CI 95% 0.07 to 0.41, P = 0.007) were found. Conversely, although a significant increase in LM (3.76 ± 0.72 kg, CI 95% 2.29 to 5.23, P = 0.001) was observed, TMT (0.05 ± 0.12 cm, CI 95% -0.3 to 0.19, P = 0.634) and SMI (0.33 ± 0.17 kg/height2, CI 95% -0.01 to 0.68, P = 0.057) did not change. When BIA and US were compared, we found a significantly correlation between the FM and SF (pre-surgical: r =0.42, P = 0.01; post-surgical: r =0.52, P = 0.003) and between SMI and TMT (pre-surgical: r =0.35, P = 0.04; post-surgical: r =0.38, P = 0.03). Lastly, MOCA score significantly increased after BS (1.13 ± 0.52, CI 95% 0.06 to 2.19, P = 0.04).
Conclusions: Our results suggest that US evaluation of TMT and SF may be complementary to BIA-derived SMI assessment for estimating muscle mass. Likewise, we also detected a possible improvement in the cognitive function of patients after BS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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