ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Uricemia in hypertensive type 2 diabetics: the forgotten metabolic parameter
Faten Haj Kacem Akid , Hamdi Frikha , Cyrine Chehaider , Ameni Salah , Dhoha Ben Salah , Mouna Mnif , Nadia Charfi , Fatma Mnif , Nabila Rekik Majdoub , Mouna Elleuch & Mohamed Abid
Hedi Chaker University Hospital, Department of Endocrinology, Sfax, Tunisia
Introduction: Hyperuricemia is a common metabolic feature in patients with metabolic syndrome.
Aim: The aim of our work is to study the correlation between uric acid level and the metabolic profile in hypertensive type 2 diabetic patients.
Methods: This is a retrospective descriptive study of hypertensive type 2 diabetic patients followed in the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia between 2019 and 2021. Hyperuricemia was defined as uric acid level ≥ 360 μmol/L
Results: 100 patients were included. Mean age was 62.14 ± 12.7 years with a sex ratio (M/F) of 0.65. Diabetes has been diagnosed since 13.73 ± 9.6 years on average with a mean HbA1c of 11.06 ± 2.5%. Hyperuricemia was found in 23.75% of cases overall and in 29.41% of patients with diabetic nephropathy (DN). Uricemia was inversely correlated with HDL cholesterol levels ( r =-0.31, P = 0.009) and creatinine clearance ( r =-0.35, P = 0.05). On the other hand, uricemia was positively correlated with triglyceride levels (r =+0.7, P = 0.009), duration of diabetes (r =+0.3, P = 0.05), and albuminuria level (r = +0.45, P = 0.02). There was no significant association between uric acid and LDL cholesterol, HbA1c, BMI, total cholesterol, and blood pressure (systolic and diastolic). Uric acid was correlated primarily with renal function in type 2 diabetics. Our results also showed a significant association between uric acid levels and triglyceride and HDL levels, which could be attributed to a fructose-enriched diet.
Conclusion: Hyperuricemia has been found to correlate with major metabolic parameters in patients with diabetes notably those with DN. Its importance contrasts with the paucity of studies about its cardiovascular effects and the lack of clear guidelines regarding its management.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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