Endocrine Abstracts

Introduction: Breathe Well-being Diabetes Reversal Program (BDRP) delivers personalized lifestyle management (LSM) curriculum including education, lifestyle, and health-related content, based on patient’s health profile and preferences. The program assists the physicians in making clinical decisions by providing comprehensive lifestyle data, which facilitates patient adherence and aids in achieving positive health outcomes.

Objective: To estimate the long-term impact of digitally administered BDRP on lifestyle measures in individuals with T2DM in India

Methodology: BDRP provides a 4-month digitally administered LSM intervention with additional stress reduction module- a “Happiness and Lifestyle Coach” combined with meditation. Individuals with T2DM were divided in 3 cohorts (1:1:1) treated with (a) BDRP with doctor-prescribed medication (n = 60), (b) BDRP with doctor-prescribed medication and personalized stress reduction module (n = 61), (c) Only doctor-prescribed medication (control group; n = 60). After 4-months of intervention, cohorts 1 and 2 with high (H: >70%) and medium (M: ≥50%-<70%) adherence and cohort 3 were followed up to 19 months. Informed consent was obtained.

Results: Of 60 and 61 individuals in cohorts 1 and 2, 46.7% (28) and 54.1% (33) showed H and M adherence. In H and M cohort 1, BMI (kg/m²) reduced from 32.6 and 31.2 at baseline to 29.5 and 28.7 at 19 months (P = 0.003; P = 0.000), respectively. In H and M cohort 2, BMI reduced from 32.9 and 31.9 at baseline to 29.7 and 28.7 at 19 months (P = 0.001; P = 0.000), respectively. Body weight (kg) in H and M cohort 1 reduced from 90.2 and 85.4 at baseline to 81.6 and 78.4 at 19 months (P = 0.003; P = 0.000). For H and M cohort 2, body weight reduced from 88.1 and 88.0 at baseline to 79.8 and 79.2 at 19 months (P = 0.001; P = 0.000). In control group, BMI and body weight reduced from 32.0 and 88.1 to 31.8 and 87.5 (P = 0.029; P = 0.025). At 19 months, HbA1c levels <6.5% were observed in 78.6% and 81.8% individuals in H and M cohorts 1 and 2. Penn State Worry Questionnaire (PSWQ) score average changed from 57.5 and 55.5 to 42.1 and 42.1 for cohort 1 (H and M), and 54.9 and 59.8 to 33.9 and 41.0 for cohort 2 (H and M) at 19 months, respectively.

Conclusion: Clinically meaningful reductions in BMI, body weight, HbA1c, and stress levels were observed in both cohorts. Cohort 2 showed greater improvement in stress levels than cohort 1. Study findings supported the promising role of digitally administered BDRP on lifestyle measures of individuals with T2DM.