Endocrine Abstracts

COVID-19 has a significant effect on the patient’s well-being even after the norm of laboratory parameters.The patients had cognitive blunting breathlessness, headache, fatigue, myalgia, weakness etc. The symptoms could last 3–12 months, from mild to severe, can lead to death.

Purpose: To determine the significance of some biomarkers characterizing the condition of a patient with diabetes mellitus after undergoing covid.

Materials and Methods: We examined 27 patients with type 2 diabetes who underwent Covid-19 4 months ago. This was the first group. The average age was 62.3 years, the duration of diabetes was 6.8 years. Glycated hemoglobin was 8.1%. The second group consisted of 18 patients without a new coronovirus infection and comparable to the patients of the first group by sex, age, duration of the disease, the level of glycated hemoglobin, complications of diabetes and concomitant diseases. The severity of of dysfunctions was assessed in points. We investigated: glycated hemoglobin (BioRad), haptoglobin, ceruloplasmin, c-reactive protein, D-dimers (ACL TOP 700 Instrumentation Laboratory), Klotho protein (ELISA).

Results: The Klotho protein levels in the first group were significantly lower than in the patients of the second group (P = 0,024), while the level of other indicators in these groups did not differ significantly. We noted a significant relationship between the severity of polyfunctional disorders in diabetic patients after a new coronovirus infection and the level of Klotto protein. The Klotto of protein level significantly negatively correlated with the level of glycated hemoglobin (r = -0.8, P = 0.023) and the level of c reactive protein (r =-0.72, P = 0,039).

Conclusion: The Klotho protein can be a biomarker of the "postСovid-19 syndrome" in patients with type 2 diabetes who have undergone a new coronavirus infection