ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Growth Assessment and Metabolic Syndrome (MetS) Criteria in children with steroid-sensitive Nephrotic syndrome (SSNS) and frequent relapses treated with long-term prednisone therapy (LTPT): Comparison between children who developed obesity versus those who did not develop obesity
Mostafa Elbaba 1 , Ashraf Soliman 1 , Noor Hamed 1 , Fawzia Alyafei 1 , Maya Itani 2 , Fatima Al-Naimi 2 , Doaa Al Yousef 2 & Mona Shaat Dalees 2
1Hamad Medical Center, Pediatrics, Doha, Qatar; 2Hamad Medical Center, Nutrition and Dietitic Department, Doha, Qatar
Introduction: Long term prednisone therapy (LTPT) can be associated with overweight, obesity, and short stature. Both LTPT and obesity are considered risk factor for the occurrence of the different components of the metabolic syndrome (MetS).
Aim: We studied steroid-associated metabolic and clinical adverse events in children with NS and frequent relapses treated with LTPT (obese vs non-obese).
Methods: Data of 30 children with SSNS was analysed retrospectively. 16/30 were obese after LTPT and 14 were not obese. The cumulative dose of steroids over 5 years was calculated for each child. Growth and different components of the metabolic syndrome (MetS) including impaired fasting glucose (IFG), high LDL and cholesterol, lower HD and high blood pressure were studied over this period and compared with the data for 66 age-matched obese non-nephrotic children.
Results: Analysis of data showed that children with NS who developed obesity during therapy were significantly taller than the normal weight group. The obese group had higher cholesterol, TG and LDL level compared to the non-obese group. Both groups had high prevalence of hypertension (40% in the obese group vs 35.7% in the non-obese group)
| At Diagnosis | Age (yr) | WAZ | HAZ | BMI | BMISD | Albumin | TG | LDL | HDL | Cholesterol | FBG | |
| years | g/l | mmol/l | mmol/l | mmol/l | mmol/l | mmol/l | ||||||
| Group 1 | mean | 3.59 | 0.33 | 0.09 | 16.23 | 0.38 | 17.33 | 2.06 | 6.06 | 2.12 | 10.04 | 5.28 |
| n =16 | SD | 1.98 | 0.72 | 0.68 | 1.33 | 0.81 | 4.29 | 0.75 | 3.06 | 1.45 | 2.66 | 0.74 |
| Group 2 | mean | 4.41 | 0.07 | -0.78 | 17.00 | 0.86 | 18.13 | 2.89 | 7.15 | 1.92 | 10.16 | 5.17 |
| n =14 | SD | 2.31 | 0.76 | 1.19 | 1.18 | 0.89 | 4.69 | 1.74 | 3.67 | 1.05 | 3.05 | 0.96 |
| After 5 y | ||||||||||||
| Group 1 | mean | 5.06 | 1.32* | -0.4* | 21.5* | 1.97* | 32.53 | 2.3* | 5.7* | 2.26 | 9.1* | 5.66 |
| n =16 | SD | 3.79 | 0.87 | 1.00 | 3.99 | 0.71 | 11.27 | 0.06 | 1.53 | 0.54 | 0.90 | 0.69 |
| Group 2 | mean | 5.43 | -0.50 | -1.14 | 16.82 | 0.05 | 37.57* | 0.93 | 4.90 | 2.29 | 7.61 | 5.58 |
| n =14 | SD | 3.18 | 0.77 | 1.30 | 1.80 | 0.61 | 7.69 | 0.04 | 3.54 | 0.72 | 4.24 | 1.00 |
| *P <0.05 group 1 vs group 2.Group 1 Children with NS who became obese on LT prednisone therapy.Group 2: Children with NS who did not become obese on LT prednisone therapy. | ||||||||||||
Conclusion: In children with SSNS on LTPT the development of obesity was associated with higher components of the MetS compared to the non-obese group advocating a higher risk to develop the cardiovascular and metabolic consequences.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more