Endocrine Abstracts

The purpose of the study is to study the F=features of the angiography of the eye bottom in patients with diabetic retinopathy in patients with type 2 diabetes mellitus (DM2), with different stages of diabetic retinopathy (DR).

Material and research methods: 252 people were examined (n=504), of which 168 patients with type 2 type and 84 practically healthy persons. The main group (I; n=174) with DM2, divided into subgroups, depending on the stage of DR: Easy non-proliferative DR (NDR), moderate NDR, severe NDR and PDR. As a comparison group (II; n=162), patients are included without clinical manifestations of others (III; n=168) - the control group was almost healthy faces without significant ophthalm and somatic pathology.All patients conducted a standard and specialized ophthalmological examination. Optical coherent tomography in the angio mode is made using an Optical Cherent Tomograph RevOFC with an angiography module with a 3 × 3 mm scan area. The level of VEGF in serum was evaluated by solid-phase immunoassy analysis using Quantikine ELISA sets.

Results: Analysis of the blood flow density indicates a significant decrease (P0.05) of this indicator in a subgroup of patients with a type of type 2 without DR and an average NDR on average by 3-5% compared with the control group. While with a moderate NDR - this figure is reduced by 12%, with a severe NDR - by 17%, at DA, by 19%. The area of the phases at DM 2 of the type without OB was higher than the norm by 21%, with a light NDRT 24%, with a moderate NDR - by 28%, with a heavy NDR - by 56%, with a PDR - to 62%.

Conclusions: Detected depletion of the peripheolar vascular drawing among patients without clinical signs of others.