Endocrine Abstracts

Introduction: Hyperuricemia is increasingly being considered a potential pathogenic factor for T2DM, metabolic syndrome, and several adverse consequences of vascular disease. It has been suggested that xanthine oxidase may underlie the urine acid-T2DM association. The study aimed to determine the associations between clinical parameters, glucose homeostasis, and SXO activity in patients with T2DM.

Methods: 125 patients with T2DM, age (58.9±9.4) years. Determined WC, HC, ratio WC/HC, BMI, FBG, PBG, fasting insulin, serum urine acid (SUA), HOMA_IR, QUICKI, Caro, HOMA_β%, HOMA_S%, and SXO activity.

Results: It was found that in the total group patients with T2DM SUA depends on SXO activity (r=0.34; P=0.007). The total group established the presence of association SXO activity with fasting insulin (r=0.45; P=0.001), HOMA_β% (r=-0.34; P=0.021), HOMA_S% (r=-0.52; P=0.00001), QUICKI (r=-0.35; P=0.016), Caro (r=-0.40; P=0.007). No sexually significant differences have been established according to SUA and SXO activity in groups with different control of glycemia.

Conclusions: The patients with T2DM SUA are linearly associated with SXO activity regardless of the state of the control of glycemia serum for activity and nonlinearly associated with other parameters of glucose homeostasis. The patients with high SXO activity are by character significant higher fasting insulin, faster secretory activity of β-cells, low faster oral insulin sensitivity, and more pronounced manifestations of insulin resistance compared to patients with normal SXO activity. The level of SXO activity in patients with T2DM, regardless of the state of the control of glycemia, is determined by the SUA (t=2.52; P=0.02) and WC/HC (t=2.87; P=0.007). In patients with optimal control of glycemia, SXO activity determines fasting insulin (t=2.68; P=0.015), with suboptimal control and high risk – age (t=-2.74; P=0.015) and HOMA_IR (t=2.62; P=0.02).