ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Impact of bariatric surgery on cognitive function
Maria-José Barahona 1 , Andreu Simó 1 , Montse Ibarra 1 , Mireia Libran 1 , Montse Ramos 1 , Veronica Perea 1 , Aida Orois 1 , Carmen Quirós 1 & Laura Casas 2
1Hospital Universitari Mútua Terrassa, Endocrinology Department, Terrassa, Spain; 2Hospital Universitari Mútua Terrassa, Neurology Department, Terrassa, Spain
Aim: Obesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Bariatric surgery (BS) is an effective means of weight reduction in severely obese patients and correlates with improvements in neurocognition. The mechanisms underlying these improvements are not fully elucidated.
Material and Methods: Prospective, observational study, including consecutive patients that underwent Y-de- Roux gastric bypass at our center. Fat mass (FM %) and appendicular skeletal mass index (ASMI) (kg/m2) by dual-energy X-ray absorptiometry (DXA) and Neurocognitive Test Battery (NTB) were assesed in all patients 1 month prior BS and 12 months after BS.
Results: From a cohort of 75 patients, 15 were selected as they completed 12 months of follow-up data. Almost all patients were female (87%), mean age (56±8 years), pre-BS BMI 43±5 kg/m2, % total weight loss 28±5. Eleven patients had diabetes (2 T1D, 9 T2D), 4 of them were treated with insulin and excluded for the calculation of HOMA. FM% (55±5 vs 44±7), ASMI (7.4±1.6 vs 6.7±1.2) and HOMA-IR (9.23±6 vs 2.28±1.4) significantly decreased 12 months after BS (P<0.005). Furthermore, patients had better performance (raw score and scaled score) in Free and Cued Selective Reminding Test (25.4±5.4 vs 29.4±5.5; 9.2±2 vs 11.2±2), visual immediate memory (16.6±10.6 vs 21.8±8.4; 9.5±4.5 vs 12±3.4), visual delayed memory (17.6±10 vs 20±8; 10.3±4 vs 11.5±3) and Boston Naming Test (52.9±4.5 vs 54.4±3.7; 11.8±2.3 vs 13±2.2) (P<0.005). After regression analysis, the only independent predictor for each post-BS performance test was the performance of those tests in pre-BS, not related to changes in body composition or HOMA-IR.
Conclusions: Our preliminary results suggest improvements on verbal and visual memory and language function after BS. Both memory and language depend on temporal lobe structures. These improvements seem not to be related to body composition or insulin resistance. Larger series are needed in order to confirm these preliminary results.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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