ECE2022 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (318 abstracts)
Correlation between pulse wave velocity and microangiopathy in type 2 diabetes
Chayma Besrour 1 , Rojbi Imen 1 , Ben Ahmed Habib 2 , Mekni Sabrine 1 , Mchirgui Nadia 1 , Ben Nacef Ibtissem 1 & Khiari Karima 1
1Hospital Charles Nicolle, Endocrinology, Tunis, Tunisia; 2Hospital Charles Nicolle, Cardiology, Tunis, Tunisia
Introduction: Microangiopathy is defined as damage to small blood vessels, and more particularly arterioles and arteriolar capillaries that supply organs. It can occur under different conditions and it represents a complication of diabetes. The aim of this study was to examine the relationship between microangiopathic complications and arterial stiffness in type 2 diabetes.
Methods: We conducted a prospective study including 249 diabetic patients without macroangipathic complications, between July 2020 and May 2021. Using a SphygmoCor®XCEL device, we measured arterial stiffness directly by the carotid to femoral pulse wave velocity (cfPWV).
Results: The mean age of the study population was 57.53±9.34 years (139 women and 110 men). The mean duration of the disease was 10.2 years.Microangiopathic complications were found in 58.2% of the patients.In this group, cfPWV was at 14.41±2.84 m/s VS 12.56±2.42 m/s in patients without microangiopathic complications (P<0.001).Moreover, the presence of arterial stiffness multiples by 4 the risk of microangiopathic complications (Odds Ratio =4).The ROC curve that we established to find a threshold value of the cfPWV from which this correlation appears, had an area under the curve equal to 0.694. The discriminate threshold value having the best sensitivity/specificity pair was 13.45 m/s.
Conclusion: Arterial stiffness is often increased in type 2 diabetes. Its presence contributes to the development of microangiopathic complications. Which leads us to believe that the early prevention of arterial stiffness may delay microangiopathy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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