Endocrine Abstracts

The purpose of the work: to compare the changes in the global longitudinal strain of the left ventricle in obese patients with and without COPD.

Material and methods of research: group I consisted of obese patients without COPD (n=50; 21 - males, mean age - 48.8±9.1 years). Group II – 40 patients with obesity and COPD, comparable in age, gender. Group III – 37 patients with COPD without obesity, comparable in age, gender and risk group of COPD, group A was in 7, group B – in 16, group C – in 5, group D – in 9 patients (GOLD, 2021).

Exclusion criteria: secondary forms of obesity, persons with a BMI <18 kg/m2. BMI, waist circumference, hip circumference, their ratio, visceral obesity index (VAI) and percentage of adipose tissue content according to Deurenberg, cardiometabolic risk on the CMDS scale, fat-free mass index (FFMI) and appendicular skeletal muscle mass index (ASMI) were evaluated. All patients in remission underwent standard echocardiography (EchoCG) with estimated global LV strain in the longitudinal direction (Global Longitudinal strain-GLS) using the “AFI” option.

Results: unlike conventional echocardiographic parameters, speckle-tracking echocardiography revealed a significant deterioration in global LV strain in the II group compared to the I group (-14.4%±2.4% vs. -16.3%±1.8%, P=0.04). At the regional level, LV apical septum tension was reduced in I group (P=0.003) in the presence of metabolically unhealthy obesity. Patients of group I and III have a deterioration of GLS that correlated with the severity of COPD (P=0.02), the visceral obesity index VAI and a decrease in the appendicular lean mass index.After adjustment for clinical and echocardiographic characteristics, MUHO in patients was independently associated with changes in GLS (95% confidence interval was from 0.98 to 2.11, P0.001).

Conclusion: the deterioration of global LV longitudinal strain is determined in 66% of patients in the presence of metabolically unhealthy obesity (vs 26% without obesity, p<0.001). The negative dynamics of GLS is associated with the severity of COPD, visceral obesity and low muscle mass.