Endocrine Abstracts

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. The aim of this presentation is to report tow cases of a virilizing androgen-secreting adrenal oncocytoma.

Case description: Case 1: A 27-year-old female was admitted to our clinic with a 116 mm left adrenal incidentaloma. The patient’s main symptom was hirsutism. Upon investigation, elevated values of testosterone, and DHEA-S were found. Contrast-enhanced abdominal CT and MRI scans revealed a heterogenous large left mass (diameter 116 × 95 mm) with necrotic areas, and a clear distinction from the adjacent structures. The patient underwent a surgical adrenalectomy. The histological examination of the tumor revealed a borderline adrenocortical oncocytoma. Case 2: A 25 years-old woman, presenting a recent and progressive virilization syndrome. Hormonal evaluation showed elevated serum testosterone and delta-4-androstenedione levels, normal urinary free cortisol level and incomplete suppression of cortisol at the 1 mg dexamethasone suppression test. CT scan of the abdomen revealed a 60×50 mm right adrenal mass. The patient benefited from an adrenelectomy. The histological examination of the tumor revealed a benign adrenocortical oncocytoma