Endocrine Abstracts

Thyroid dysfunction is common, and thyroid function tests (TFTs) are amongst the most frequently requested laboratory measurements, both in the adult and paediatric setting. Fortunately, most TFTs are straightforward to interpret and confirm a clinical diagnosis of eu-, hypo- or hyperthyroidism. In most cases, the underlying cause of thyroid dysfunction is readily apparent from clinical findings and standard investigations (e.g. antibody testing, radionuclide scan). In a subse...

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Childhood obesity is a highly prevalent, chronic, and progressive disease. While lifestyle therapy is the cornerstone of obesity treatment, this intervention is usually ineffective for achieving clinically significant and durable BMI reduction. The limitations of lifestyle therapy stem from the fact that this intervention does not address the underlying pathophysiology of obesity. Anti-obesity pharmacotherapy, in contrast, directly addresses the pathophysiology, thereby enhanc...