SFEBES2021 Poster Presentations Reproductive Endocrinology (31 abstracts)
The rate of progression of atherosclerosis in menopause is associated with levels of circulating amyloid beta 1-40
Eleni Armeni 1,2 , Dimitrios Delialis 1 , Georgios Georgiopoulos 1,3 , Simon Tual-Chalot 4 , Nikolaos Vlachogiannis 4 , Raphael Patras 1 , Evmorfia Aivalioti 1 , Areti Augoulea 1 , Nikolaos Tsoltos 1 , Anastasia Soureti 1 , Konstantinos Stellos 4 , Kimon Stamatelopoulos 1 & Irene Lambrinoudaki 1
1National and Kapodistrian University of Athens, Athens, Greece; 2University College Hospital, London, United Kingdom; 3St. Thomas’ Hospital, London, United Kingdom; 4Newcastle University, Newcastle, United Kingdom
Background: Cardiovascular disease remains the leading cause of death worldwide, affecting both sexes. Awareness and prevention practices aiming to control cardiovascular risk in women remain inadequate. On the other hand, circulating amyloid β 1-40 (Aβ1-40) is a proatherogenic peptide, closely linked with the process of aging. We aimed to evaluate the possible association between the progression of atherosclerosis in postmenopausal women and the role of Aβ1-40 peptide, as well as its time-related pattern of change, in this population with substantial unrecognized CV-risk beyond traditional risk factors.
Methods: This prospective study of 152 postmenopausal women free of cardiovascular disease (CVD), aimed to assess carotid atherosclerosis, by using high-resolution ultrasonography and levels of Aβ1-40. Evaluation was performed at baseline and after a median follow-up of 28.2 months.
Results: Levels of Aβ1-40 at baseline associated with higher sum of maximal wall thickness in all carotid sites (sumWT) but also higher carotid bulb intima-media thickness (cbIMT) (p-value<0.05, all cases). Aβ1-40 levels increased with the progress of time, and were also linked with declining renal function (p-value <0.05, all cases). A pattern of accelerated progression of atherosclerosis was evident in women with increasing or persistently high levels of Aβ1-40, after adjusting for baseline values, renal function and traditional CV-risk factors. The pattern of atherosclerotic changes was evident in cbIMT, sumWT and maximum carotid wall thickness.
Conclusion: The progression of subclinical carotid atherosclerosis in otherwise healthy postmenopausal women is associated with increasing or persistently high levels of Aβ1-40, irrespectively of its baseline levels. The results of this study provide insights into a link between Aβ1-40 and the progression of atherosclerosis in menopause. If these findings are confirmed by larger observational studies, then Aβ1-40 might serve as an atherosclerosis biomarker in women without clinically overt CVD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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