SFEBES2021 Poster Presentations Metabolism, Obesity and Diabetes (78 abstracts)
Associations between reduction in body mass index (BMI) and proteins linked to neural function after 12 months of bariatric surgery
Helene Fachim 1,2 , Zohaib Iqbal 2 , Martin Gibson 1,2 , Ivonna Baracevic-Jones 2 , Amy Campbel 2 , Bethany Geary 2 , Rachelle Donn 2 , Akheel Syed 1,2 , Antony Whetton 2 , Handrean Soran 2 & Adrian Heald 1,2
1Salford Royal NHS Foundation Trust, Salford, United Kingdom; 2The University of Manchester, Manchester, United Kingdom
Background: Bariatric surgery (BS) can have significant effects on multiple body systems and has been an effective intervention for morbid obesity, improving many comorbid medical conditions that are associated with mental health and cognitive dysfunction. It was previously shown that cognitive impairment was partly reversible in obese patients after BS [1], however, the effects of BS on proteins associated to central nervous system (CNS) still unknown. We evaluated if there are associations between changes in body mass index (BMI) after BS and circulating proteins.
Methods: SWATH MS proteomics was performed on serum samples taken at baseline (pre-surgery), 6 and 12 months after BS and concurrent analyses of inflammatory/metabolic parameters carried out. Change in absolute abundances of those proteins showing significant change at both 6 and 12 months was tested for correlation with absolute and percentage change in BMI.
Results: BMI declined significantly at 6 (t=9.29, P < 0.0001) and 12 (t=7.82, P < 0.0001) months. Significant correlations between % change in BMI (6 months X baseline) and fold change in the following proteins: APOM (r = 0.639, P = 0 .047), APOA4 (r = 0.649, P = 0 .042), PGLYRP (r = 0.650, P = 0 .042), HSPG2 (r = 0.760, P = 0 .048), SERPIND1 (r = 0.788, P = 0 .007). At 12 months post-BS, we found correlations between TF (r = 0.682, P = 0 .043), ITIH3 (r = 0.695, P = 0 .038), L1CAM (r = 0.788, P = 0 .02) and AMBP (r = 0.697, P = 0 .037).
Conclusions: Specific group of proteins were associated with percentage change in BMI in two different time points. At 6 months post-surgery evidencing proteins related to lipid transport, circulatory system and immunity, while at 12 months, proteins related to important brain functions, such as synaptic plasticity and neuronal function. These results suggest that changes in circulatory proteins related to brain functions may reveal an important BS outcome after 12 months associated with weight loss. Future studies are needed to clarify underlying mechanisms in how BS may influence neural functions, such as cognition and memory.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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