SFEBES2021 Poster Presentations Adrenal and Cardiovascular (45 abstracts)
The ULTRADIAN consortium - Ambulatory in vivo micro dialysis in primary adrenal insufficiency, preliminary data
Georgina Russell 1 , Thomas Upton 1 , Eder Zavala 2 , Paal Methlie 3 , Katerina Simunkova 3 , Katerina Berinder 3 , Ileena Botusan 4 , Dimitria Vassiliadi 5 , Stelios Tsagarakis 5 , Olle Kämpe 4 , Eystein Husebye 3 , Stafford Lightman 1 , Marianne Øksnes 3 & Sophie Bensing 4
1University of Bristol, Bristol, United Kingdom; 2University of Birmingham, Birmingham, United Kingdom; 3University of Bergen, Bergen, Norway; 4Karolinska Institute, Stockholm, Sweden; 5Evangelisnos Hospital, Athens, Greece
Patients on long term glucocorticoid replacement therapy have higher rates of morbidity and mortality. One causative factor may be non-physiological cortisol replacement. We have developed as part of the ULTRADIAN consortium (https://www.uib.no/en/ultradian) the U-RHYTHM, an ambulatory bio-sampling device that can collect clinical samples using in-vivo microdialysis every 20 minutes over the 24hour day whilst individuals continue with their normal everyday activities. We sampled 46 patients with a confirmed diagnosis of primary adrenal insufficiency (Addison’s) on hydrocortisone (n = 31), cortisone acetate (n = 9), Plenadren (n = 5) and continuous subcutaneous pump treatment (n = 1). Here we present examples of the individual dynamic cortisol and cortisone profiles in these patients compared to the data from n = 223 healthy volunteers using a toolkit of mathematical techniques that extract information from fluctuating hormone levels. We identified significant deviations in the timing, magnitude of glucocorticoid dynamics, and a range of detectable adrenal steroids in all Addisons patients. The observed variability was present regardless of glucocorticoid replacement type, further reinforcing that current treatment options do not mimic normal physiology. This knowledge will allow for the development of replacement therapies that more closely mimic normal physiology and may be personalised according to age, sex, body mass index, chronotype.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more