SFEBES2021 Poster Presentations Bone and Calcium (22 abstracts)
Vitamin D deficiency and inflammation in IBD patients
Iulia Soare 1 , Anca Sirbu 1,2 , Mircea Diculescu 1,3 , Bogdan Radu Mateescu 1,4 , Cristian Tieranu 1,5 , Luminita Cima 1,2 & Simona Fica 1,2
1University of Medicine and Pharmacy ”Carol Davila”, Bucharest, Romania; 2Endocrinology Department, Elias Emergency Hospital, Bucharest, Romania; 3Gastroenterology Department, Fundeni Clinical Institute, Bucharest, Romania; 4Gastroenterology Department, Colentina Hospital, Bucharest, Romania; 5Gastroenterology Department, Elias Emergency Hospital, Bucharest, Romania
Introduction: Vitamin D is a potential immune modulator and low levels are common in inflammatory bowel disease (IBD) patients. The aim of the study was to determine the association between deficient vitamin D and inflammatory profile.
Methods: Intestinal (fecal calprotectin) and blood inflammatory profile [erythrocytes sedimentation rate (ESR), protein C reactive, fibrinogen], were performed to all patients. In addition, level of 25 hydroxy vitamin D was determined and patients were divided into deficient (25 hydroxy vitamin D <20 ng/ml), and sufficient group (25 hydroxy vitamin D >=20 ng/ml).
Results: 62 patients IBD patients (median age 45 (IQR 24) years; mean age at diagnosis, 34.9 (± 14.1 SD) years and median duration of the disease, 6 (IQR 11) years) were included in this study. Mean 25 hydroxy vitamin D level was 20.9± 8 ng/ml SD. Deficient vitamin D level was seen in 43.5% of the patients. When compared between the two groups, protein C reactive was significantly higher in deficient group (2.14 (IQR 10.9) vs 0.8 (IQR 2.05) mg/dl, P = 0 .007). Moreover, all inflammatory markers were higher in deficient vitamin D group, fibrinogen (309 (IQR 122) vs 299 (IQR 96) mg/dl, P = 0 .4), (ESR 14 (IQR13) vs 9 (IQR14) mg/dl, P = 0 .6), fecal calprotectin (100 (IQR 275) vs 30 (IQR115) mg/g, P = 0.06), although they did not reach statistically significance.
Conclusions: Our study showed that vitamin D deficiency is common in IBD patients. Higher inflammatory profile was found in deficient patients and vitamin D intervention studies are warranted in order to find if its correction will decrease inflammation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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