Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2021) 77 BPW2.1 | DOI: 10.1530/endoabs.77.BPW2.1

SFEBES2021 Basic Physiology Workshops Model systems (3 abstracts)

Modelling diabetes using iPSCs and adult derived organoids

Rocio Sancho


King’s College London, London, UK.


Loss of beta cell mass in the pancreas characterises type 1 and late-stage type 2 diabetes, resulting in a reduction of insulin levels. The pancreas has a very limited regenerative potential during homeostasis. Despite its quiescent nature, recent in vivo models suggest that a certain degree of regeneration and cellular interconversion is possible in the adult pancreas. The molecular regulation of this plasticity shares remarkable similarities with pancreas beta cell differentiation during development, however, the identity of the plastic cells remains elusive. Using iPSCs and adult ductal derived organoids we have uncovered new fundamental regulatory networks and cell populations involved in pancreatic cell fate decisions during homeostasis and diabetes. The use of iPSCs- and adult- derived organoids offers novel therapeutic avenues and new strategies for modelling diabetes in a dish.

Volume 77

Society for Endocrinology BES 2021

Edinburgh, United Kingdom
08 Nov 2021 - 10 Nov 2021

Society for Endocrinology 

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