Endocrine Abstracts

Aim of the study: To assess vitamin D levels in centenarians and its interaction with the most common geriatric syndromes

Materials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. QoL questionnaires were used as well. In all patients we measured 25OH vitamin D levels. In one year after the investigations we contacted patients’ relatives or social workers to find out about patients’ status. The statistical analysis was performed using IBM SPSS Statistics Version 26. Statistically significant were differences with P<0,05.

Results: Mean age of the patients was 98.3 (±1.9) years, while 87.8% of the cohort were women. Analyzing functional status we found out that 34.4% of the patients were frail, and the number of prefrail patients was 56.2%. Cognitive impairments of different severity were presented in 84.4% of the patients. Median vitamin D levels was 9.6 (6.9; 16.2) ng/ml. So in our group, 70 (86%) patients had vitamin D deficiency, 9 patients (12%) had vitamin D isufficiency and in only 3 patients (2%) we found vitamin D levels within the normal range. While comparing functional status and QoL with vitamin D profile we discovered positive correlation between vitamin D levels and Barthel index (r=0.348), vitamin D levels and iADL (r=0.436) and vitamin D and MNA (r=0.389) (P less then 0.05).

Conclusion: Low vitamin D levels severely influence functional status, cognitive functions and QoL of older people, hence it is absolutely necessary to assess its levels in this population and restore them timely.