Endocrine Abstracts

Objectives: The aim is to systematically review the evidence among the eligible primary studies in which the relationship between dietary patterns and risk of obesity/overweight in children and/or adolescents aged 3-17 years in China was assessed.Methods: Bibliographic databases such as Medline (Ovid), were searched. Medical Subject Headings (MeSH) terms, synonyms or alternative terminologies, acronyms were included. The quality of included studies was a...

Objectives: To report outcomes comparing RYGB (Roux-en-Y gastric bypass) and OAGB (one anastomosis gastric bypass) on patients with obesity. To further investigate the efficacy of OAGB, given that there is significant interest in OAGB as it has reported reduced operating time, better weight loss and increased remission of obesity-related comorbidities. However, there are concerns over potentially serious postoperative complications causing limited uptake.<p class="abstext"...

Background: Patients with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD), despite insulin therapy. Insulin resistance is strongly associated with non-alcoholic fatty liver disease (NAFLD) and CVD. The euglycemic clamp, the gold standard to assess insulin resistance in T1D, is unsuited for clinical practice. The estimated glucose disposal rate (eGDR) is increasingly used as an alternative in T1D, but its role as a NAFLD or CVD predictor is unexplor...

Background: Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Early detection of PCa faces severe limitations as PSA displays poor-specificity. Therefore, new diagnostic and therapeutic alternatives are urgently needed.Objectives: This work was aimed to investigate the miRNA landscape in PCa and explore their putative diagnostic/therapeutic utility.Methods: The miRNome of plasma sampl...

Background: Prostate cancer (PCa) diagnosis is based on the serum levels of prostatic specific antigen (PSA), which might be influenced by many clinical conditions, including obesity. In addition, the diagnostic capability of PSA test dramatically drops when considering patients with PSA levels lower than 10ng/mL (i.e. “grey-zone”). Therefore, the identification of more reliable non-invasive diagnostic biomarkers for PCa is a critical unmet clinical need. In this sce...

Background: Hormonal signalling plays a key role in the progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). However, the role of somatostatin (SST), cortistatin (CORT), neuronostatin (NST) and ghrelin systems in NAFLD-HCC progression has not been elucidated.Objectives: To characterize the role of SST/CORT/NST and ghrelin systems in chronic liver disease and evaluate its clinical potential.Met...

Background: Apart from traditional cardiovascular-risk factors and fluctuating sex hormone levels, environmental and lifestyle factors might also contribute to the heightened cardiovascular risk after menopause.Objective: To explore whether nutritional factors are associated with subclinical vessel disease in postmenopausal women.Methods: This cross-sectional study recruited 310 apparently healthy postmenopausal women, attending a ...

Background: Glioblastomas (GBMs) remain the deadliest human brain tumors, with a poor prognosis despite years of research. Currently, standard therapeutic strategies to treat GBM are not efficient, and the overall survival is ˜14 months. Thus, the identification of new therapeutic tools to battle GBMs is crucial. In this sense, many metabolic drugs (e.g., metformin (MF) and simvastatin (SVT)) have emerged as putative antitumor agents for certain endocrine-related cancers,...

Background: Gliomas are the most common primary brain tumor, being astrocytomas a subset of malignant gliomas graded on a scale of I to IV. Grade-IV astrocytomas (glioblastoma multiforme; GBM) are the most malignant and aggressive type. Current standard treatments are ineffective, being their average postoperative survival of 12-16 months. Therefore, there is a clear need for the identification of novel therapeutic targets to treat this pathology. In this context, the truncate...

Objectives: Pre-clinical medical education is mainly delivered in didactic large-group lectures, where complex new terminology and concepts are introduced. Mounting evidence suggests that pre-class activities introducing new material can increase student performance. Concise Medical Information Cines (CoMICs) compresses information on various diseases into 5-minute videos. This study assessed the effectiveness of CoMICs as a pre-lecture resource to enhance learning and motivat...

Background: The COVID-19 pandemic restricted face-to-face teaching leading to increased use of virtual learning platforms. Launched in 2019, Simulation via Instant Messaging – Birmingham Advance (SIMBA) delivers simulation-based learning to increase clinicians’ confidence in managing various clinical scenarios.Objective: To explore SIMBA’s effectiveness to sustain medical education in endocrinology during the pandemic.<p class="abstext...

Objectives: The Tier 3 Weight Management (WM) service is a comprehensive pathway for people with a Body Mass Index (BMI) >40 or >35 with complications. This study aimed to describe the clinical characteristics and outcomes in patients referred to the WM service in Birmingham and Solihull (BSol).Methods: This was a retrospective health service evaluation of adults consecutively referred to the BSol WM service from March 2017 to April 2018. Data wa...

Background: An endocrine disruptor is an exogenous chemical or mixture of chemicals that interfere with any aspect of hormone action. It can interfere with the body’s endocrine system and produce adverse cardiovascular, neurological, developmental, reproductive, and metabolic effects in humans. This study aims to evaluate the knowledge, attitude, and practices (KAP) of the medical students regarding the exposure, usage, and long-term harmful effects of Endocrine Disrupt...