Endocrine Abstracts

Introduction: Diagnostic markers to detect Diabetic Kidney Disease (DKD) at an early stage are important. Neutrophil to Lymphocyte ratio (NLR) is an easily available parameter to assess the inflammatory status of the subject and has shown its usefulness in prognostication of Cardiovascular diseases and Malignancy. Very few studies have explored the association between NLR and DKD in the North-Eastern Indian population with type 2 diabetes mellitus.

Objectives: To estimate Neutrophil–Lymphocyte ratio in patients with and without DKD. To study its co-relation with DKD.

Methods: This cross-sectional study was conducted in Gauhati Medical College. 135 Type 2 DM patients who gave consent and satisfied the inclusion criteria were included in the study. Demographical Data was be analyzed by descriptive statistics and expressed as mean with standard deviation. The co -relation was assessed between NLR and patients without proteinuria, with microalbuminuria and macro-albuminuria using SPSS software and computer-based randomization.

Results: Amongst 135 individuals in the study, the mean age of the study population was 54.44±11.69 years. The female-to-male ratio is 1.071: 1. The mean duration of disease was 6.2 ± 4.8 years. The mean BMI was 25.8±7.2 The mean NLR was higher in patients with microalbuminuria (3.33±1.7) and macro-albuminuria (4.88±2.77) compared to those without proteinuria (2.29±1.55) and was of statistical significance. The 24hour protein, creatinine and e-GFR was also statistically significant between these groups.

Conclusion: The NLR was significantly higher in patients with micro-albuminuria and macro-albuminuria compared to patients without proteinuria. It can be considered as a surrogate marker for the detection and prognostic purposes of Diabetic Kidney Disease. We hope this study adds to the existing data and paves way to future, well matched, prospective studies which may define in detail about the temporal correlation between NLR and DKD.