ECE2021 Presented Eposters Presented ePosters 4: Reproductive and Developmental Endocrinology (8 abstracts)
Chungbuk National University, Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Republic of South Korea
Decamethylcyclopentasiloxane(D5) is one of the most common chemical ingredient for cosmetic products, cleansing agents, hairdye, dry cleaning solvent and personal hygiene supplies. D5 is also known as estrogenic chemical. It can be absorbed through skin, airosol, and even oraly. People are exposed to D5 in daily environment. However, the risk of prenatal exposure to D5 has not yet been fully understood. Recent research shows that imbalance of dams estrogen induces brain development disorder, in this study the effect of prenatal exposure of D5 on brain development were assessed by behavioral test of their pup. According to previous study, the estimated amount of daily exposure of D5 to human is around 0.6 mg/kg. Also, the systematical absorption ratio of D5 by oral is 10% in mice. Thus, we treated 3, 6, 12, 60 mg/kg of D5 with corn oil per a day to pregnant female mice from E10 through E19. All behavioral tests were performed after pups became 6 weeks old. In high dose treated D5 group showed decreased social behavior and cognitive ability in three chamber test. The impairment of memory and exploring ability were found on high dose D5 group pups in novel object test. These results show that maternal exposure to D5 impairs social ablilty and memory of pups. As pups were only exposed to D5 in prenatal period, these symptoms were caused by abnormal brain development while they were embryos. This study shows that maternal exposure to D5 cause the offsprings brain development disorders. Also, the results support the previous study that imbalance of estrogen disrupts brain development.