ECE2021 Presented Eposters Presented ePosters 2: Diabetes, Obesity, Metabolism and Nutrition (8 abstracts)
Inuyama Chuo General Hospital, Diabetes, Inuyama-City, Japan
There is little information regarding inter-individual variability of accuracy for CGM and flash glucose monitor (FGM) sensors. We studied the possibility of inter-individual variability of accuracy for CGM and FGM sensors. This is a prospective study. During hospitalization, 10 patients with type 2 diabetes wore a CGM [iPro2] and FGM [FreeStyle Libre Pro] in parallel over 24 h while every pre- and post-prandial venous blood glucose levels (VBG) were measured and used to calibrate CGM (n of VBG measurement = 60). We evaluated mean absolute difference (MAD) and mean absolute relative difference (MARD), derived from sensor glucose levels (SG) for CGM, measured every 5 min (MAD 5 min and MARD 5 min) and extracted every 15 min (MAD 15 min and MARD 15 min), and derived from SG for FGM, measured every 15 min (MAD FGM and MARD FGM). The study participants correlated to the distribution of VBG (correlation ratio: η2 = 0.38 P = 0.003). The study participants correlated to the distribution of MAD 5 min and that of MAD 15 min (η2 = 0.27 P = 0.04998, η2 = 0.27 P = 0.047, respectively); however, the study participants did not correlate to the distribution of MARD 5 min and that of MARD 15 min. However, the study participants correlated to the distribution of MAD FGM and that of MARD FGM (η2 = 0.57 P < 0.001, η2 = 0.52 P < 0.001, respectively). The result of VBG may have been caused by patient-to-patient differences in glycemic control. The results of MAD for CGM may have been caused by the fact that higher VBG may lead to higher MAD. The results of MARD for CGM may have been caused by the fact that VBG are not associated with MARD because MARD is percentage of MAD to VBG. Compared of the result of MARD for FGM to the result of MARD for CGM, the correlation between the study participants and distribution of MARD FGM may suggest the inter-individual variability of accuracy for FGM sensors.