ECE2021 Presented Eposters Presented ePosters 12: Diabetes, Obesity, Metabolism and Nutrition (8 abstracts)
Relationship between adiponectin, TNFα and SHBG in prepubertal children with obesity
Marta Ramon-Krauel 1 , Maria Jesus Leal-Witt 1 , Oscar Osorio-Conles 1 , Montse Amat-Bou 1 , Carles Lerin 1 & David Martinez 2
1Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Endocrinology, Barcelona, Spain; 2Vall d’Hebron Research Institute (VHIR), Autonomous University of Barcelona (UAB), Diabetes and Metabolism, Barcelona, Spain
Sex hormone-binding globulin levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. The main objective of this study was to assess if the adult associations between TNFα, Adiponectin and SHBG are present in prepubertal children. We determined several morphometric and biochemical parameters in normal-weight and obese prepubertal children, as well as quantified plasma SHBG, TNFα-R1, and adiponectin levels. Our results showed that prepubertal children with obesity had decreased plasma SHBG levels compared to normal-weight controls (67 nmol/l vs 172 nmol/l). Importantly, SHBG plasma levels correlated significantly (P < 0.05) with TNFα (negatively, ßstd = -0.31) and adiponectin (positively, ßstd = 0.58) suggesting an important role of these two cytokines in determining plasma SHBG levels in prepubertal children. Furthermore, the results showed that plasma adiponectin levels are may play a more important role than TNFα in influencing plasma SHBG levels in our prepubertal population with obesity.
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more