Endocrine Abstracts

The prevalence of MS in different countries is 25–30% and varies depending on the diagnostic criteria used. The severity of the clinical manifestations of MS affects the quality of life (QL) of patients, while the indicators of physical and mental health decrease. The problem of QL of patients suffering from overweight and obesity is relevant and socially significant. Obesity leads to anxiety-depressive disorders, neurosis-like conditions, which contributes to a worsening of the prognosis of the underlying disease. The aim of the work was to assess QL, the level of anxiety, depression in patients with metabolic syndrome.

Research methods

60 patients with MS and 35 apparently healthy volunteers who did not have concomitant diseases and were not obese were examined. The study was carried out on the basis of the therapeutic department of the Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences. Examination of patients, determination of anthropometric parameters (waist circumference, body weight, BMI) with an assessment of the quality of life (questionnaire SF-36, Russian version, Institute of Clinical and Pharmacological Research, St. Petersburg). The level of anxiety and depression was determined according to the hospital scale of anxiety and depression HADS (The hospital Anxiety and Depression Scale Zigmond A.S., Snaith R.P.). The statistical significance of differences was determined using the Mann–Whitney rank test, P<0.05.

Results

Indicators of the QL level were significantly higher in healthy individuals than in patients with MS (P = 0.001). Our study revealed a decrease in the average level of the parameters ’physical functioning’ by 18.3% (P = 0.003), ’role functioning’ by 32.1% (P = 0.002), ’general health’ by 12.3% (P = 0.001), ’vitality’ by 15% (P = 0.03), ’emotional functioning’ by 51.1% (P = 0.03). The level of anxiety and depression in patients with MS corresponded to the subclinical level, the level of depression exceeded the value of the control group by 19% (P = 0.04).

Conclusion

QL in obese patients is one of the most important factors in the integrative assessment of patients’ condition, the higher the patient’s body weight, the worse his physical condition and the more pronounced concomitant diseases. Patients with MS are characterized by a decrease in quality of life indicators, subclinically expressed anxiety/depression.