Endocrine Abstracts

Introduction

The SARS-Coronavirus-2 pandemic affects 248 469 people with 28 341 deaths in Spain as of June 28, 2020. Severe infection is more prevalent in patients with advanced ages, cardiovascular risk factors (CVRF) and chronic diseases (diabetes mellitus, cardiovascular disease and asthma). Having diabetes implies vulnerability to serious complications and death from coronavirus; although, not all diabetics have the same level of risk. The oldest is present over 65 years of age. This study analyzes the profile of diabetics and baseline characteristics of those admitted for SARS-Coronavirus-2 in a third-level hospital in Granada (Andalusia, Spain).

Material and methods

Retrospective descriptive study. 102 diabetics admitted for COVID-19 treated with Glargine U100, between March 12-May 15, 2020 at Hospital Universidad San Cecilio. We reviewed electronic medical records to collect variables: gender, age, CVRF, type of diabetes, glycosylated hemoglobin (HbA1c), angiopathic complications, and home treatment.

Results

54% men. 97% diabetes mellitus 2, 2 debuts, and 0.03% diabetic due to high-dose corticosteroid therapy. Over 65 years, 76.47%. 92% associated comorbidities with diabetes: hypertension (82.35%, 60.7% were taking ACEI or AIIRA), dyslipidemia, hyperuricemia or angiopathic complications. 27.45% microangiopathic, the most frequent: 23.5% chronic kidney disease and 32.35% macroangiopathic: 13.7% cerebrovascular disease and 14.7% ischemic heart disease. At home, 36.27% were insulin dependent. 50.1% HbA1c (up to 1 previous year) lower than 7.5%. Mortality 17.65%, 88.8%> 65 years. Among the deceased, 100% hypertensive, 83% took angiotensin converting enzyme inhibitors or angiotensin receptor blockers, 100% some comorbidity and average HbA1c around 7.5%.

Conclusions

The most frequent diabetic profile hospitalized for COVID-19 has been DM 2 over 65 years with CVRF and/or angiopathic complications. It is deduced from the average HbA1c value among the deceased that diabetes per se is not a determining factor in the severity and/or mortality of the infection.