Endocrine Abstracts

Introduction

The objective of our study was to compare the glycemic control between patients on human insulin and those on insulin analogues.

Methods

We conducted a prospective, randomized and comparative study. By recruiting patients with diabetes hospitalized in the day hospital departement at the National Nutrition Institute in Tunis during 8 months. The glycemic control of patients on human insulin and those on insulin analogues was evaluated by comparing the averages of their fasting glucose level and glycated hemoglobin.We used the t-test for independent samples.

Results

We included 50 patients with diabetes, 80% with type 2 diabetes and 20% with type 1 diabetes, 60% were women and 40% were men, the average age was 49 years (± 16), the average duration of diabetes was 10 years (± 7), insulin-treated for an average duration of 5 years (± 6), 74% were on human insulin and 26% were on insulin analogues, the average body mass index was 28 (95%CI26-29), the average fasting glucose level was 10 mmol per liter (95%CI9-11), the average glycated hemoglobin was 9.5%(95%CI9-10). The average of fasting glucose level for patients on human insulin was 10 mmol/l (95% CI 8.6–11.4) and for those on insulin analogs 10.4 mmol/l (95% CI 8.4–12.3), we found no statistically significant difference between these two averages (P=0.66). The average of glycated hemoglobin for patients on human insulin was 9.67% (95%CI 9.1–10.1 ) and for those on insulin analogues 9.2% (IC95% 8.5–10%), we found no statistically significant difference between these two averages(P = 0.34).

Conclusion

In this study, we found no statistically significant difference between the glycemic control of patients on human insulin and those on insulin analogues. More studies are needed to validate these results.