Endocrine Abstracts

Introduction

Thyroid autoantibodies can detected in many disorders not only at the Hosimoto autoimmune thyroiditis. Their level and frequency may vary depending on many factors both thyroidal and nonthyroidal. Anti thyroid peroxidase autoantibodies (ATPO) is one of the well known among them. We analysed frequencies of higher level of ATPO among people with different types of thyroid diseases.

Material and methods

In 94 people blood serum ATPO, TSH, T3, T4 levels were measured in the laboratory unit of the Republican Specialized Scientific Practical Medical Centre of Endocrinology and Vitamed clinic in Tashkent. Data were collected, analysed and compared by age, gender, thyroid state and diseases.

Results

High level of antiperoxidase autoantibodies were detected in 46% of observed persons, where the mean age were 42.5 ± 3.8 years old. As noted in many studies woman composed the most part of observed persons with higher ATPO level and male patients consist about 17% among them. Thyroid state were assessed by TSH, T3, T4 level. Euthyroid goiter detected in 46% of people with high ATPO, 18% of them thyrotoxicosis, 18% with hypothyroidism, and 13% cases were thyroid cancer and 22% in healthy pregnant woman.

Conclusion

ATPO is a frequent laboratory findings reflected thyroid function. Higher level of antiperoxidase autoantibodies mostly detected in middle aged people predominantly in woman, 46% cases of high ATPO were combined with euthyreosis state, 18% with hyperthyroidism, 18% of hypothyroidism, 13% cases were with cancer.