ECE2021 Eposter Presentations Adrenal and Cardiovascular Endocrinology (21 abstracts)
Endocrinology Research Centre, Moscow, Russian Federation
Introduction
There is no consensus about the necessity of dehydroepiandrosterone (DHEA) replacement in women with adrenal insufficiency (AI).
Methods
The woman aged 44 with medical compensation of autoimmune 1-AI, 1-hypogonadism, osteoporosis took DHEA (tablets of 50 mg in every morning) during 4 months. Concomitant therapy: hydrocortisone, fludrocortisone, drospirenone+estradiol, colecalciferol, calcium carbonate.
Results
Units | Baseline | Day | Month | |||
1st | 14th | 4 | 7 (3 months after the end of therapy) | |||
DHEA-S | μmol/l | 0.003 | 5.04 | 5.72 | 5.74 | 0.003 |
SHBG | nmol/l | 102.5 | – | 108.1 | 102.2 | |
Total testosterone | 0.17 | 0.975 | 0.17 | |||
Free testosterone | pmol/l | 1.6 | 7.7 | 1.6 | ||
Estradiol | 415.7 | 396.57 | 423.6 | |||
Osteocalcin | ng/ml | 26.18 | 21.18 | 18.29 | ||
β-Cross laps | 0.64 | 0.33 | 0.36 | |||
Colecalciferol | 24.3 | 28.3 | 22.6 | |||
AMH | 1.10 | 1.17 | 1.48 | |||
Inhibin B | pg/ml | 59 | 52 | 60.7 | ||
LH | U/l | 27.6 | 14.4 | 23.9 | ||
FSH | 31.5 | 15.6 | 32.3 | |||
Glucose | mmol/l | 4.64 | 4.04 | 4.34 | ||
Cholesterol | 5.68 | 5.03 | 5.06 | |||
Insulin | μU/ml | 4.18 | 6.51 | 5.3 | ||
HbA1c | % | 5.5 | 5.5 | 5.8 | ||
Hair growth –axillary –pubic (Tanner scale) |
No V |
Yes V |
No V |
|||
Ultrasound of the pelvic, mammary glands | n | n | ||||
Cytological examination of smears | ||||||
Side effects | – | Slight greasiness of the face | ||||
Golombok-Rust Inventory of Sexual Satisfaction-Female | ||||||
Frequency | 5 | – | 5 | |||
Incommunicability | 2 | 3 | 2 | |||
Dissatisfaction | 4 | 4 | ||||
Avoidance | 2 | 0 | ||||
Anorgasmia | 3 | |||||
Vaginismus | 0 | |||||
Touch | 4 | 0 | ||||
Hospital Anxiety and Depression Scale | ||||||
Anxiety | 7 | – | 4 | 6 | ||
Depression | 3 | 2 | 1 | |||
Symptom checklist-90-revised | ||||||
Somatization | 0.75 | – | 0.5 | 0.67 | ||
Obsessive-Compulsive | 0.5 | 0.8 | 0.8 | |||
Interpersonal Sensitivity | 0.11 | 0.22 | 0.11 | |||
Depression | 0.31 | 0.23 | 0.31 | |||
Anxiety | 0.5 | 0.3 | 0.4 | |||
Hostility | 0.33 | 0.17 | 0.5 | |||
Phobic Anxiety | 0 | 0 | ||||
Paranoid Ideation | ||||||
Psychoticism | ||||||
Positive Symptom Total | 28 | 26 | 27 | |||
Global Severity Index | 0.32 | 0.29 | 0.34 | |||
Positive Symptom Distress Index | 1.04 | 1.00 | 1.15 | |||
SF-36 health status survey | ||||||
Physical health | 43.33 | – | 51.24 | 46.42 | ||
Physical Functioning | 70 | 80 | 70 | |||
Role-Physical Functioning | 0 | 50 | ||||
Bodily pain | 100 | 100 | ||||
General Health | 52 | 70 | 47 | |||
Mental health | 45.93 | 51.93 | 45.22 | |||
Vitality | 55 | 60 | ||||
Social Functioning | 75 | 75 | 62.5 | |||
Role-Emotional | 100 | 100 | 66.67 | |||
Mental Health | 52 | 76 | 68 | |||
Wechsler Memory Scale | ||||||
Visual Reproduction | 7 | – |
10 | 6 | ||
Paired Associates | 12 | 15 | 14 | |||
Digits –forward –backward |
6 5 |
6 5 |
7 4 |
Conclusion
DHEA-S reached normal values within a day after taking the drug. A positive effect on the quality of life, mood, sexual function, some types of memory, bone metabolism was found. An inverse negative relationship between DHEA-S and gonadotropins is assumed. No significant side effects were observed.
Funding
Russian Science Foundation (project 17-75-30035).