Endocrine Abstracts

Introduction

Acromegaly is an acquired endocrine pathology associated with the overproduction secondary to hypersecretion of growth hormone, by a somatotropic pituitary adenoma in more than 90% of cases, the symptoms of which may concern various organs (eye, heart, colon, etc.). skin….). Occasionally, it can present itself in association with skin changes which in some cases are very rare. We report the observation of a patient followed for acromegaly and discoid lupus

Presentation of the case

his is a 43-year-old patient, followed for acromegaly since 2014, held in front of a facial dysmorphia and on a paraclinical level on an IGF-1 level at 337 ng/ml (80–271) × 1.49 normal and pituitary MRI: pituitary macroadenoma of 24 × 17 × 27 mm somatotropic on anathomopathological examination operated twice in 2014 then resumption of surgery in February 2017 by the transphenoid route, complicated by an anterior pituitary thyreotropic and gonadotropic insufficiency started on treatment substitute Levothyrox 75 µg/d; Trisequens, with surgical failure then put on somatostatin analogues. On skin and mucous membrane examination: presence of two atrophic lesions with irregular borders surmounted by scales on both cheeks suggesting discoid lupus. At skin biopsy: Appearance compatible with lupus. The anti native DNA and antinuclear antibodies are negative.

Conclusion

The association of discoid lupus and acromegaly is exceptional, one can observe during acromegaly hypertrichosis, multiple pendulum molluscums, diffuse melanoderma or acanthosis nigricans, frontal skin signs and scalp and therefore know these associated skin lesions. at acromegaly can facilitate its diagnosis.