ECE2021 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (82 abstracts)
Macrovascular complications in adult-onset type 1 diabetes
Hadj Kacem Faten 1 , Khouloud Boujelben 1 , Allymamod Bibi Twaheerah 1 , Charfeddine Salma 2 , Charfi Nadia 1 , Mnif Fatma 1 , Mnif Mouna 1 , Rekik Nabila 1 , Kamoun Samir 2 & Abid Mohamed 1
1Hedi Chaker Hospital, Department of Endocrinology, Diabetology, Sfax, Tunisia; 2Hedi Chaker Hospital, Department of Cardiology, Sfax, Tunisia
Introduction
Type 1 Diabetes (T1D) diagnosed during adulthood is a form of diabetes which is underdiagnosed and underreported. Lower incidence of cardio metabolic risk factors such as atherogenic dyslipidemia, high blood pressure and obesity have been reported in T1D patients compared to type 2 diabetes. In this study, we aimed to determine the prevalence of and predictive factors for macrovascular complications during T1D diagnosed in adulthood.
Patients and methods
Patients over 20 years diagnosed with diabetes were included. Data from 166 patients were analyzed. Levels of antibodies to glutamic acid decarboxylase (anti-GAD), protein tyrosine phosphate (IA2) and islet cell (ICA) were quantified in all patients. T1D was diagnosed in patients testing positive for at least one of autoantibodies.
Results
The mean age was 31.81 years (range: 20–64 years). In our study, 95 were male (57.2%), and 71 (42.8%) were female. The median disease duration was 7.34 ± 6.73 years. The mean of basal metabolic index (BMI) was 21.05 kg/m2. Underweight was found in 23.5% of cases and 63.9% of patients had normal BMI. Overweight and obesity were observed in 9% and 3.6% of patients, respectively. The incidence for the composite macrovascular outcome was 7.8%. Hypertension occurred in 6% of patients after a mean diabetes duration of 16.5 ± 7.23 years (range:10–35 years). About half of those patients were grade 1 hypertensive, while 40% and 10% were grade 2 and 3 hypertensive, respectively. Coronary artery disease was observed in 2.4% of patients after a mean diabetes duration of 13.5 ± 13.77 years (range: 3–32 years). Only 3 patients (1.8%) developed peripheral arterial occlusive disease after a mean duration of 21.3 ± 15.5 years (range:10–39 years). A higher incidence of macrovascular complications among T1D adults was significantly observed in patients with longer disease duration (P < 0.5). Moreover, macrovascular complications are more prevalent among adults who were hypertensive and smokers (P < 0.05). No significant correlation was identified between obesity and macrovascular complications.
Conclusion
This research provides insights into the association between T1D diagnosed during adulthood and macrvascular complications and highlights the importance of a screening approach in order to enhance therapeutic outcome.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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