ECE2021 Audio Eposter Presentations Late Breaking (114 abstracts)
Association of thiol/disulfide homeostasis with Bethesda classification of thyroid nodules and thyroid cancer
Muhammet Cuneyt Bilginer 1 , Abbas Ali Tam 2 , Sevgul FAKI 3 , Bağdagül Yüksel Güler 4 , Ozcan Erel 5 , İbrahim Kilinç 6 , Didem Ozdemir 2 , Oya Topaloglu 2 , Reyhan Ersoy 2 & Bekir Cakir 2
1Karadeniz Technical University School of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Ankara Yildirim Beyazit Universty School of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 3University of Health Sciences Turkey, Ankara City Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey; 4University of Health Sciences Turkey, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey; 5Ankara Yildirim Beyazit Universty School of Medicine, Department of Medical Biochemistry, Ankara, Turkey; 6University of Health Sciences Turkey, Ankara City Hospital, Department of General Surgery, Ankara, Turkey
Background
Ultrasonography and fine needle aspiration biopsy are frequently used in the diagnosis of thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. In this study, we investigated whether there is a relationship between thiol/disulfide homeostasis and cytological and histopathological diagnosis of thyroid nodules.
Materials and methods
A total of 119 participants were included in the study (81 euthyroid nodular goiter patients and 28 age and body mass index matched healthy volunteers). The patient group consisted of individuals scheduled for thyroidectomy. Thyroidectomy indications were giant nodule, cytological diagnosis and patient preference. Patients with diseases that would affect thiol/disulfide homeostasis were excluded. Cytological findings, histopathology results were evaluated. Native thiol, total thiol, and disulfide concentrations were measured, and disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios were calculated. Thiol/disulfide levels were analyzed with automated spectrophotometric method.
Results
There was no significant difference in oxidative stress parameters between different Bethesda categories. However, the increasing Bethesda categories were weakly positively correlated with the disulfide/native thiol (r: 0.241, p: 0.030) and disulfide/total thiol (r: 0.250 p: 0.024). The disulfide concentration was 16.07±9.28 µmol/l in histopathologically benign, 19.85±11.28 µmol/l in malignant, and 14.87±7.62 µmol/l in the control group (P<0.001, f=11.724). Disulfide/native thiol was calculated as 3.58±2.0 in the benign group, 5.50±2.85 in the malignant group, and 3.41±1.70 in the control group (P <0.001, f=8.415). Disulfide/total thiol was significantly higher in the malignant compared to benign and control groups (4.96±2.24, 3.27±1.80 and 4.96±2.24, respectively, P <0.001, f=9.49).
Conclusion
Oxidative stress parameters were significantly higher in thyroid cancer. A weak positive correlation was detected between Bethesda categories and the disulfide/native thiol ratio and the disulfide/total thiol ratio. In case of diagnostic difficulties, additional benefit can be obtained from thiol/disulfide measurement.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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