ECE2021 Audio Eposter Presentations Late Breaking (114 abstracts)
Vitamin D deficit in type 2 diabetes patients during the winter in Northern Gran Canaria with and without supplementation
Alba Hernández Lázaro 1 , Paula María Fernandez-Trujillo-Comenge 1 , Ricardo de Leon-Durango 1 , Agnieszka Kuzior 2 , Manuel Esteban Nivelo Rivadeneira 1 , Carmen Acosta-Calero 2 , Claudia Arnas-Leon 2 , Sara Quintana-Arroyo 2 , Paula Gonzalez-Diaz 3 & Francisco Javier Martinez-Martin 2
1Hospital Universitario de Gran Canaria Dr. Negrin, Endocrinology and Nutrition, Las Palmas de Gran Canaria, Spain; 2Hospitales San Roque, Endocrinology and Nutrition, Las Palmas de Gran Canaria, Spain; 3Centro de Salud de Arucas, Primary Healthcare, Arucas, Spain
Introduction
Vitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been enforced but there was no mandatory lockdown.
Objectives
To assess the prevalence of vitamin D deficiency in type 2 diabetic patients from Northern Gran Canaria during the winter period (December 2020 to February 2021).
Methods
Plasma calcifediol levels were sampled in an unselected type 2 diabetic population, along with age, gender and vitamin D supplementation status.
Results
Data were obtained from 227 consecutive patients, 133 female (58.6%), mean age 59.7 ± 14.7 years. 103 (45.4%) were taking vitamin D supplements. Mean plasma calcifediol was 31.2 ± 13.0 ng/ml; but it was lower than recommended (<30 ng/ml), in 50.2% of the patients, deficient (<20 ng/ml) in 20.3% and severely deficient (<12 ng/ml) in 5.3%. In supplemented patients, calcifediol was mostly adequate (mean 41.1 ± 10.7 ng/ml, with 15.5% < 30 ng/ml, 3.9% < 20 ng/ml, none < 12 ng/ml and none > 80 ng/ml) but low in unsupplemented patients (mean 23.0 + 8.2 ng/ml, with 79.0% < 30 ng/ml, 34.7% < 20 ng/ml and 9.3% < 12 ng/ml). Plasma calcifediol was significantly higher in supplemented patients (mean difference 18.1 ng/ml, unpaired t-test, P < 0.0001) and the proportions of low, deficient and severely deficient patients were significantly lower (Fisher’s exact test, P < 0.0001, P < 0.0001 and P = 0.0006, respectively). Female patients had slightly higher plasma calcifediol than males (mean difference 4.1 ng/ml, unpaired t-test, P = 0.019). There was an inverse correlation between age and plasma calcifediol (coefficient -0.091, P = 0.004).
Conclusions
Even without a mandatory lockdown, the prevalence of low calcifediol levels during the winter months in our unsupplemented type 2 diabetic population is extremely high. However, when taking vitamin D supplements their vitamin D status is satisfactory with < 4% deficient patients and none severely deficient. Their use was effective to prevent the deprivation associated with voluntary lockdown, social gathering restrictions and low insolation during wintertime.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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