ECE2021 Audio Eposter Presentations Thyroid (157 abstracts)
Thyroid pathologies in acromegaly
Ajili Rihab , Hasni Yosra , Ben Abdelkarim Asma , Saad Ghada , Kacem Maha , Maaroufi Amal , Chaieb Molka & Ach Koussay
Farhat Hached Sousse, Endocrinology, Tunisia
Introduction
Acromegaly is a rare disease, but serious in its complications. It is a multisystemic pathology also affecting the thyroid. The aim of our work is to study thyroid involvement in acromegaly.
Patients and methods
This is a retrospective study of acromegalic patients, in the endocrinology department of Sousse over a period of 20 years.
Result
These are 40 acromegaly patients, with a sex ratio (M/F) of 0.74. The mean age was 38.9 years [13-77]. The mean IGF1 level was 937 ng/ml [367–1700]. Anterior pituitary insufficiency was present in 32.5% of cases and thyrotropic insufficiency in 17.5% of cases. Thyroid ultrasound was performed in 20 patients. It was normal in 12 patients (60%). A multi-nodular goiter was found in a quarter of the cases and it was indicative of the disease in one case. Nodules on a normal-sized thyroid were found in 20% of cases. Fine needle aspiration was performed in two patients, showing a benign appearance. A thyroid scintigraphy done in three patients showed one cold and two hot nodules. There was no correlation between the level of IGF1 and the onset of goiter.
Discussion and conclusion
It is well established that acromegaly can affect pituitary function, including the thyrotropic axis. On the other hand, it is associated with an increased prevalence of goiter, as thyroid follicular cells express IGF-I receptors. Studies suggest a positive relationship between thyroid volume and elevated serum IGF-I levels. Hence the interest of a systematic exploration of the thyroid to the discovery of acromegaly and during the follow-up.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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